"Laboratorio Nacional de Investigación y Desarrollo de Radiofármacos"

imagen inin


Rojas-Calderón EL, Ávila O, Ferro-Flores G. Monte Carlo calculations of the cellular-S-values for alfa-particle-emitting radionuclides incorporated into the nuclei of cancer cells of the MDA-MB231, MCF7 and PC3 lines. Applied Radiation and Isotopes (2018) 135:1-6.

Azorín-Vega, E.; Rojas-Calderón, E.; Martínez-Ventura, B.; Ramos-Bernal, J.; Serrano-Espinoza, L.; Jiménez-Mancilla, N.; Ordaz-Rosado, D.; Ferro-Flores, G., Assessment of cell death mechanisms triggered by 177 Lu-anti-CD20 in lymphoma cells. Applied Radiation and Isotopes (2018) 138:73-77.

Marmolejo-León P, Azorín-Vega E, Jiménez-Mancilla N, Mendoza-Nava H, Mitsoura E, Torres-García E. Estimation of the effectiveness ratio (alfa/beta) for resistant cancer cells in U87MG human glioblastoma. Appl. Rad. Isot. (2018)

Ferro-Flores G, Ocampo-García B, Santos-Cuevas C, Jiménez-Mancilla N, Luna-Gutiérrez M, Ramírez F de M, Morales-Avila E, De León-Rodríguez LM, Azorín-Vega E. Chapter 52 "Preparation of Heterobivalent and Multivalent Radiopharmarmaceuticals to Target Tumors Over-expressing Integrins" in “Integrin targeting systems for tumor diagnosis and therapy” from the series Methods in Pharmacology and Toxicology, Edited by Eleonora Patsenker. Springer, New York, p. 69-92 (2018).

Ferro-Flores G, Ocampo-García B, Santos-Cuevas C, Luna-Gutierrez M, Azorín-Vega E, Jiménez-Mancilla N. 99mTc-EDDA/HYNIC-iPSMA as a radiopharmaceutical for detecting the overexpression of prostate-specific membrane antigen. Patent Corporation Treaty Application (PCT). Patent No. WO2017222362 (2017). 

Ramírez-Nava G, Santos-Cuevas C, Ocampo-García B, Chairez-Oria I, Díaz-Nieto L, García-Quiroz J.Multimodal molecular 3D imaging for the tumoral volumetric distribution assessment of folate-based biosensors. Med Biol Eng Comput (2017)

Meléndez-Alafort L, Rosato A, Ferro-Flores G, Penev I, Uzunov N. Development of a five-compartmental model and software for phrmacokinetic studies. Compt. Rend. Acad. Bulg. Sci. (2017) 70(12): 1646-1654.

Ancira-Cortez A, Morales-Avila E, Ocampo-García B, González-Romero C, Medina LA, López-Tellez G, Cuevas-Yañez E. Preparation and characterization of tumor-targeting dual-image system based on iron oxide NPs functionalized with folic acid and rhodamine. J Nanomaterials (2017) ID 5184167.

Luna-Gutiérrez M., Hernández-Jiménez T., Serrano-Espinoza L., Peña-Flores A., Soto-Abundiz A., Freeze-dried multi-dose kits for the fast preparation of 177Lu-Tyr3-octreotide and 177Lu-PSMA(inhibitor) under GMP conditions. Journal of Radioanalytical and Nuclear Chemistry, (2017) 314: 2181-2188. DOI: 10.1007/s10967-017-5595-1.

Escudero-Castellanos A., Ocampo-García B., Ferro-Flores G., Isaac-Olivé K., Santos-Cuevas C., Olmos-Ortiz A., García-Quiroz J., García-Becerra R., Díaz L, Preparation and in vitro evaluation of 177Lu iPSMA RGD as a new heterobivalent radiopharmaceutical. Journal of Radioanalytical and Nuclear Chemistry (2017) 314:2201-2207. DOI: 10.1007/s10967-017-5555-9.

Carrillo-Cazares A., Jiménez-Mancilla N., Luna-Gutiérrez M.A., Isaac-Olive K.,Camacho-Lopez M. Study of the optical properties of functionalized gold nanoparticles in different tissues and their correlation with the temperature increase. Journal of Nanomaterials, Volume 2017, Article ID 3628970: 1-9, DOI: 10.1155/2017/3628970 (2017).

Auletta S, Baldoni D, Varani M, Galli F, Hajar IA, Duatti A, Ferro-Flores G, Trampuz A, Signore A. Comparison of 99mTc-UBI 29-41, 99mTc-Ciprofloxacin, 99mTc-Ciprofloxacin dithiocarbamate and 111In-biotin for targeting experimental Staphylococcus aureus and Escherichia coli foreign-body infections: an ex-vivo study. The Quarterly Journal of Nuclear Medicine and Molecular Imaging, DOI: 10.23736/S1824-4785.17.02975-2 (2017).

Jaimes-Aguirre L, Morales-Avila E, Ocampo-García B, Medina LA, López-Tellez G, Gibbens-Bandala B, Izquierdo-Sánchez V. Biodegradable poly (D, L-lactide-co-glycolide)/poly (L-gamma-glutamic aci) nanoparticles conjugated to folic acid or targeted delivery of doxorrubicin. Mat. Sci. Eng. C (2017) 76:743-751.

González-Ruíz, A.; Ferro-Flores, G.; Azorín-Vega, E.; Ocampo-García, B.; de Maria Ramírez, F.; Santos-Cuevas, C.; De León-Rodríguez, L.; Isaac-Olivé, K.; Luna-Gutiérrez, M.; Morales-Ávila, E., Synthesis and in vitro evaluation of an antiangiogenic cancer-specific dual-targeting 177Lu-Au-nanoradiopharmaceutical. Journal of Radioanalytical and Nuclear Chemistry, 314(2):1337-1345 (2017).

Mendoza-Nava, H.; Ferro-Flores, G.; Ramírez, F. d. M.; Ocampo-García, B.; Santos-Cuevas, C.; Azorín-Vega, E.; Jiménez-Mancilla, N.; Luna-Gutiérrez, M.; Isaac-Olivé, K., Fluorescent, Plasmonic, and Radiotherapeutic Properties of the 177Lu–Dendrimer-AuNP–Folate–Bombesin Nanoprobe Located Inside Cancer Cells. Molecular Imaging 16: 1-10 (2017)

Gibbens-Bandala B, Ocampo-García B, Ferro-Flores G, Morales-Avila E, Ancira-Cortez A, Jaimes-Aguirre L. Multimeric system of RGD-grafted PMMA-nanoparticles as a targeted drug-delivery system for paclitaxel. Current Pharmaceutical Design 23:3415-3422 (2017).

Ocampo-García B., Santos-Cuevas C., Luna-Gutiérrez M., Ignacio-Alvarez E., Pedraza-López M., Manzano Mayoral C., 99mTc-exendin(9-39)/octreotide: Biokinetics and Radiation Dosimetry in Healthy Subjects and Imaging of Insulinoma in Patients. Nuclear Medicine Communications 38: 912-918 (2017).

Morales-Avila, E.; Ferro-Flores, G.; Ocampo-García, B. E.; López-Téllez, G.; López-Ortega, J.; Rogel-Ayala, D. G.; Sánchez-Padilla, D., Antibacterial Efficacy of Gold and Silver Nanoparticles Functionalized with the Ubiquicidin (29–41) Antimicrobial Peptide. Journal of Nanomaterials, Volume 2017, Article ID 5831959, 12 pages. (2017).

Santos-Cuevas, C.; Davanzo, J.; Ferro-Flores, G.; García-Pérez, F. O.; Ocampo-García, B.; Ignacio-Alvarez, E.; Gómez-Argumosa, E.; Pedraza-López, M., 99mTc-labeled PSMA inhibitor: Biokinetics and radiation dosimetry in healthy subjects and imaging of prostate cancer tumors in patients. Nuclear Medicine and Biology 52: 1-6 (2017).

Ferro-Flores G, Luna-Gutiérrez M, Ocampo-García B, Santos-Cuevas C, Azorín-Vega E, Jiménez-Mancilla N, et al. Clinical translation of a PSMA inhibitor for 99m Tc-based SPECT. Nuclear Medicine and Biology 48: 36–44 (2017).

Ramírez F de M, Palomares-Castillo K, Ocampo-García B, Morales-Avila E, Varbanov S. Physicochemical behaviour of a dinuclear uranyl complex formed with an octaphosphinoylated para-tert-butylcalix [8] arene. Spectroscopic studies in solution and in the solid state. Polyhedron 123:75-89 (2017)

Cornejo-Aragón, L. G.; Santos-Cuevas, C. L.; Ocampo-García, B. E.; Chairez-Oria, I.; Diaz-Nieto, L.; García-Quiroz, J., Preclinical Biokinetic Modelling of Tc-99m Radiophamaceuticals Obtained from Semi-Automatic Image Processing.  J Med Biol Eng (2017) 37:887-898.

Azorín-Vega, E. P., Papel de las Proteínas de Matriz Extracelular en la Radioresistencia de las Células Tumorales Hipofisiarias. Revista Latinoamericana de Física Médica  2 (2), 100-103 (2016).

Escudero-Castellanos A., Ocampo-García B.E., Domínguez-García M. V., Flores-Estrada J., Flores-Merino M.V. Hydrogels based on poly(ethylene glycol) as scaffolds for tissue engineering application: Biocompatibility assessment and effect of the sterilization process. Journal of Materials Science: Materials in Medicine 27:176 (2016) .

Mendoza-Nava H., Ferro-Flores G., Ocampo-García B.E., Ramírez F. de M., Santos-Cuevas C.L., Isaac-Olivé K. 177Lu-dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity: A potential theranostic radiopharmaceutical. Journal of Nanomaterials, Volume 2016, Article ID 1039258:1-11. (2016).

Jaimes-Aguirre L., Gibbens-Bandala B., Morales-Avila E., Ocampo- Garcí, B., Seyedeh-Fatemeh M., Amirhosein A. Polymer-Based Drug Delivery Systems, Development and Pre-Clinical Status. Current Pharmaceutical Design 22: 2886-2903 (2016).

Aranda-Lara L., Ferro-Flores G., Azorín-Vega E., Ramírez F. de M., Jiménez-Mancilla N., Ocampo-García B.E., Santos-Cuevas C.L., Isaac-Olivé K. Preparation and preclinical evaluation of Lys1(Folate)Lys3(177Lu-DOTA)-Bombesin(1-14) as a potential theranostic radiopharmaceutical for breast cancer. Applied Radiation and Isotopes 107:214-219 (2016).

Aranda-Lara L., Ferro-Flores G., Ramírez F. de M., Ocampo-García B.E., Santos-Cuevas C.L., Díaz-Nieto L., Isaac-Olivé K. Improved Radiopharmaceutical Based on 99mTc-Bombesin-Folate for Breast Tumor Imaging. Nuclear Medicine Communications 37: 377-386 (2016).

López-Rodríguez V., Galindo-Sarco C., García-Pérez F.O., Ferro-Flores G., Arrieta O., Ávila-Rodríguez M.A. PET-Based Human Dosimetry of the Dimeric αvβ3 Integrin Ligand 68Ga-DOTA-E-[c(RGDfK)]2, a Potential Tracer for Imaging Tumor Angiogenesis. Journal of Nuclear Medicine 57(3):404-409 (2016).

Ferro-Flores G., Ávila-Rodríguez M.A., García-Pérez F.O. Imaging of Bacteria with Radiolabeled Ubiquicidin by SPECT and PET Techniques. Clinical and Translation Imaging 4: 175-182 (2016). DOI: 10.1007/s40336-016-0178-7.

Azorín-Vega E.P., Zambrano-Ramírez O.D., Rojas-Calderón E.L., Ocampo-García B.E., Ferro-Flores G. Tumoral Fibrosis Effect on the Radiation Absorbed Dose of 177Lu-Tyr3-octreotate and 177Lu-Tyr3-octreotate conjugated to gold nanoparticles. Applied Radiation and Isotopes 100: 96-100 (2015).

Pérez A, Santos-Cuevas CL, Chairez I, Poznyak T, Ordaz-Rosado D, García-Becerra R, Romero Piña ME. Ozone Dosage Effect on C6 Cell Growth: in Vitro and in Vivo Tests. Anticancer Agents Medicinal Chemistry 15(9) 1190-1196 (2015)

López-Rodríguez V., Gaspar-Carcamo R.E., Pedraza-López M., Rojas-Calderón E.L., Arteaga de Murphy C., Ferro-Flores G., Avila-Rodríguez M.A. Preparation and preclinical evaluation of 66Ga-DOTA-E-(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nuclear Medicine and Biology 42(2) 109-114 (2015).

Orocio-Rodríguez E., Ferro-Flores G., Santos-Cuevas CL, Ramírez F. de M., Ocampo-García BE, Azorín-Vega E, Sánchez-García F. Two Novel Nanosized Radiolabeled Analogues of Somatostatin for Neuroendocrine Tumor Imaging. Journal of Nanoscience and Nanotechnology 15(6) 4159-4169 (2015).

Ferro-Flores G., Ocampo-García B.E., Santos-Cuevas C.L., Ramírez F. de M., Azorín-Vega E.P., Meléndez-Alafort L. Theranostic Radiopharmaceuticals Based on Gold Nanoparticles Labeled with 177Lu and Conjugated to Peptides. Current Radiopharmaceuticals 8(2) 150-159 (2015).

Sánchez‑Hernández L., Ferro‑Flores G., Jiménez‑Mancilla N., Luna‑Gutiérrez M.A., Santos-Cuevas C.L., Ocampo-García B.E., Azorín-Vega E., Isaac-Olivé K.  Comparative Effect between Laser and Radiofrequency Heating of RGD-Gold Nanospheres on MCF7 Cell Viability. Journal of Nanoscience and Nanotechnology 15: 9840-9848 (2015).

Medina-García V., Ocampo-García B., Ferro-Flores G., Santos-Cuevas C., Aranda-Lara L., García-Becerra R., Ordaz-Rosado D., Meléndez-Alafort L. A Freeze-Dried Kit Formulation for the Preparation of Lys27(99mTc-EDDA/HYNIC)-Exendin(9-39)/99mTc-EDDA/HYNIC-Tyr3-Octreotide to Detect Benign and Malignant Insulinomas. Nuclear Medicine and Biology 42:911-916 (2015).